Amit Reddi

Regents’ Professor, School of Chemistry & Biochemistry

Metals and metalloproteins are integral components of virtually every metabolic and signaling pathway of consequence to human health and disease. The Reddi laboratory seeks to elaborate on the multifaceted roles of transition metals in biochemistry, placing an emphasis on cancer cell biology. Our lab is currently deciphering the cellular and molecular mechanisms by which the abundant metalloprotein, Cu/Zn Superoxide Dismutase, regulates a casein kinase important in Wnt signaling and control of respiratory vs. fermentative energy metabolism, processes that are central to the pathology of numerous cancers. To achieve our aims, we employ cutting-edge techniques that lie at the interface of biochemistry, inorganic chemistry, biophysics, chemical biology, molecular genetics, and cell biology.