Our lab is interested in the study of glycans (sugars) that are involved in cellular differentiation and cancer progression in a field of study known as glycomics. The posttranslational modification of proteins with glycans changes significantly during development and in the presence of diseases such as cancer. These glycan modifications play important roles in establishing the functions of proteins. We are applying glycoproteomic techniques to identify glycoproteins with tumor-specific glycosaylation changes in a variety of human cancers. These glycoprotein biomarkers can be evaluated for use as diagnostic and/or therapeutic targets.