Lyon's research interests center around the development and implementation of new polymeric materials for bioanalytical and biomedical applications. The group mainly focuses on the design of hydrogel nanoparticles with architectures that are tailored to the desired application. For example, we have developed nanogels with precise core/shell architectures for the targeted delivery of oligonucleotides (e.g. siRNA, microRNA). Other polymer nanomaterials have been developed for use in responsive interfaces/thin films, surfaces that control cellular (eukaryotic and prokaryotic) cell adhesion and proliferation, bioanalytical sensing, and controlled drug delivery.